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UN committee finds weed killer glyphosate unlikely to cause cancer (¿?)

22 May, 2016
UN/WHO panel in conflict of interest row over glyphosate cancer risk. theguardian.com. May 17, 2016. Chairman of UN’s joint meeting on pesticide residues co-runs scientific institute which received donation from Monsanto, which uses glyphosate. A UN panel that on Tuesday ruled that glyphosate was probably not carcinogenic to humans has now become embroiled in a bitter row about potential conflicts of interests. It has emerged that an institute co-run by the chairman of the UN’s joint meeting on pesticide residues (JMPR) received a six-figure donation from Monsanto, which uses the substance as a core ingredient in its bestselling Roundup weedkiller. Read also, IARC: Glyphosate, probably carcinogenic to humans
UN committee finds weed killer glyphosate unlikely to cause cancer (¿?)
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Roundup weedkiller Glyphosate is a core ingredient in Roundup weedkiller, made by Monsanto. Photograph: Studioshots/AlamyProfessor Alan Boobis, who chaired the UN’s joint FAO/WHO meeting on glyphosate, also works as the vice-president of the International Life Science Institute (ILSI) Europe. The co-chair of the sessions was Professor Angelo Moretto, a board member of ILSI’s Health and Environmental Services Institute, and of its Risk21 steering group too, which Boobis also co-chairs.
In 2012, the ILSI group took a $500,000 (£344,234) donation from Monsanto and a $528,500 donation from the industry group Croplife International, which represents Monsanto, Dow, Syngenta and others, according to documents obtained by the US right to know campaign.
Alan Boobis said: “My role in ILSI (and two of its branches) is as a public sector member and chair of their boards of trustees, positions which are not remunerated. The boards of trustees are responsible for oversight of the organisations and their scientific programmes.”
But the news sparked furious condemnation from green MEPs and NGOs, intensified by the report’s release two days before an EU relicensing vote on glyphosate, which will be worth billions of dollars to industry.
Vito Buonsante, a lawyer for the ClientEarth group, said: “There is a clear conflict of interest here if the review of the safety of glyphosate is carried out by scientists that directly get money from industry. This study cannot in any way be reliably considered when deciding whether to approve glyphosate.”
The Green MEP Bart Staes said: “The timing of the release of this report by the FAO/WHO could be described as cynical, if it weren’t such a blatantly political and ham-fisted attempt to influence the EU decision later this week on the approval of glyphosate.”
The WHO says that from its side, the timing of the report’s release so close to the EU decision was coincidental, and was decided several months ago.
The debate over glyphosate, the most widely used herbicide in human history, has become a lightning rod in Brussels, because of its widespread use with crops genetically engineered to resist it. Its use has also been led to reports of associated damage to human health, nearby flora, insects and animals.
The debate over the scientific bona fides of the ILSI also has a fractious back story. In 2012, the European parliament suspended funding to the European food safety authority (Efsa) for six months over a string of conflicts of interest allegations involving ILSI members on the board of Efsa and on its committees.

Supermarkets and garden centres ban Roundup weedkiller suspected of causing cancer Read moreThe dispute saw the resignation of the chair of the Efsa management board, as well as Moretto standing down as a member of the Efsa pesticides panel, for failing to declare links with the industry and ILSI. An advisory position held by Boobis at Efsa was discontinued in 2012. At that time, ILSI described itself as a “key partner for European industry”, but it now says that it is a non-profit guided by scientific and environmental concerns and that it does not lobby or make policy recommendations.
This description of the group was endorsed Dr Philippe Verger, a WHO official and secretary of the UN panel on glyphosate. He said that ILSI could best be called a “meeting place” for scientific discussions.
Verger told the Guardian: “ILSI is not an independent body. That is very clear. Private companies are supporting it and its structure. But the objective of ILSI and of the companies is to create a space for discussion and interaction between the private and public sectors. ILSI’s focus is not to discuss topics of economic interest for individual companies. It is more of a forum.”
The UN panel’s conflict of interest explainer says that it will exclude experts who have “forms of economic relations that may undermine [their] neutrality”.
Greenpeace was not convinced, however. Its EU food policy director, Franziska Achterberg, said: “Even Efsa – not exactly a poster child when it comes to impartiality – doesn’t allow scientists tied to ILSI to sit on its expert panels. Any decision affecting millions of people should be based on fully transparent and independent science that isn’t tied to corporate interests.”
In common with an Efsa assessment that also attracted anger from environmentalists, the JMPR’s decision was taken on the basis of confidential industry dossiers not available to the public.
A separate report last year by the International Agency for Research on Cancer (IARC) – WHO’s cancer agency – which only considered publicly available studies, concluded that glyphosate was probably carcinogenic to humans. But WHO officials maintain there is no contradiction between the two papers, noting that IARC was identifying a potential hazard, whereas the JMPR was quantifying the associated risk.
Verger said: “Every year we evaluate 10-30 compounds, and I can tell you that a lot of them are more dangerous and potent than glyphosate. We are a bit uncomfortable that there is so much interest in this assessment, [just] because this particular pesticide is used for GM crops.” _____________________________________________________________________________________________________________________ Read also: JOINT FAO/WHO MEETING ON PESTICIDE RESIDUESGeneva, 9–13 May 2016SUMMARY REPORT
1.2 Glyphosate (158)Glyphosate is a broad-spectrum systemic herbicide. Several epidemiological studies on canceroutcomes following occupational exposure to glyphosate were available. The evaluation of thesestudies focused on the occurrence of NHL. Overall, there is some evidence of a positive associationbetween glyphosate exposure and risk of NHL from the case–control studies and the overall metaanalysis.However, it is notable that the only large cohort study of high quality found no evidence ofan association at any exposure level. Glyphosate has been extensively tested for genotoxic effectsusing a variety of tests in a wide range of organisms. The overall weight of evidence indicates thatadministration of glyphosate and its formulation products at doses as high as 2000 mg/kg body weightby the oral route, the route most relevant to human dietary exposure, was not associated withgenotoxic effects in an overwhelming majority of studies conducted in mammals, a model consideredto be appropriate for assessing genotoxic risks to humans. The Meeting concluded that glyphosate isunlikely to be genotoxic at anticipated dietary exposures. Several carcinogenicity studies in mice andrats are available. The Meeting concluded that glyphosate is not carcinogenic in rats but could notexclude the possibility that it is carcinogenic in mice at very high doses. In view of the absence ofcarcinogenic potential in rodents at human-relevant doses and the absence of genotoxicity by the oralroute in mammals, and considering the epidemiological evidence from occupational exposures, theMeeting concluded that glyphosate is unlikely to pose a carcinogenic risk to humans from exposurethrough the diet. The Meeting reaffirmed the group ADI for the sum of glyphosate and its metabolitesof 0–1 mg/kg body weight on the basis of effects on the salivary gland. The Meeting concluded that itwas not necessary to establish an ARfD for glyphosate or its metabolites in view of its low acutetoxicity.
Issued 16 May 2016

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