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Social, health, and genetic aspects of the people affected by glyphosate in Ecuadorian border

26 July, 2011
Baseline determination in social, health, and genetic areas in communities affected by glyphosate aerial spraying on the northeastern Ecuadorian border. César Paz-y-Miño, María José Muñoz, Adolfo Maldonado, Carolina Valladares, Nadia Cumbal, Catalina Herrera, Paulo Robles, María Eugenia Sánchez and Andrés López-Cortés. Reviews on Environmental Health 2011 26:1 , 45-51. Abstract: The northeastern Ecuadorian border has undergone aerial spraying with an herbicide mix that contains surfactants and adjuvants, executed by the Colombian Government. The purpose of this study was to diagnose social, health, and genetic aspects of the people affected by glyphosate. For this objective to be achieved, 144 people were interviewed, and 521 medical diagnoses and 182 peripheral blood samples were obtained. Genotyping of GSTP1 Ile105Val, GPX-1 Pro198Leu, and XRCC1 Arg399Gln polymorphisms were analyzed, using PCR-RFLP technique. The assessment of chromosomal aberrations was performed, obtaining 182 karyotypes. Malnutrition in children was 3%. Of the total population, 7.7% had children with malformations, and the percentage of abortions was 12.7%. Concerning genotyping, individuals with GSTP1 Val/Val obtained an odds ratio of 4.88 (p<0.001), and Ile/Val individuals, together with Val/Val individuals, had an odds ratio of 2.6 (p<0.05). In addition, GPX-1 Leu/Leu individuals presented an odds ratio (OR) of 8.5 (p<0.05). Regarding karyotyping, the 182 individuals had normal karyotypes. In conclusion, the study population did not present significant chromosomal and DNA alterations. The most important social impact was fear. We recommend future prospective studies to assess the communities.
Social, health, and genetic aspects of the people affected by glyphosate in Ecuadorian border
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