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Publicación electrónica del Sertox. Registrada en el Centro Argentino de Información Científica y Tecnológica - CONICET - Centro Nacional Argentino del ISSN. Es distribuida gratuitamente y de carácter mensual.
N° 52 - September 2007
Boletín Electrónico Mensual del Servicio de Toxicología del Sanatorio de Niños de Rosario, Ar. Año 4

ISSN 1668-0928

[ Informan / Escriben] [ Noticias del Sertox] [ Toxicología al día] [ Aportes] [ La prensa] [ zNo sólo de tóxicos] [ Recomendamos]

Editorial: The era of toxics

We had thought about titling this editorial, Is it China's fault? because of  toothpastes contaminated with harmful ethyln glycol, toxic in pet foodtoys with lead… and now foods non apt for the human consumption. So one of recommended press articles of this month begins, questioning products exported by  China [See].  In a recent article we said: "If we consider the increasing number of chemicals that can produce toxic situations and their diversity of uses and processes, it is easy to understand that in the practice of  clinical toxicology,  new situations appear…" . We should now add "and  other situations which were considered forgotten, must be updated , such as the risk of being exposed to lead with the toys.  It seams to be evident the impact that China's growing industry is having in many countries around the world  [See] That relationship between China's need of a growing international market, and the standards of the local manufacture process and certificates, as well as enforcement mechanisms, may well be a challenge for both export and import partners. Controls showed to appear inefficients in the United States ; same thing happened in Spain; this author wanders about what would be happening in Latin American, weaker in terms of control resources. Recent dramatic examples, as it was the epidemic of ethylene glycol related diseases that took place in Nicaragua(2006) may support the concern. In "When the toys become ill", we encouraged  the enforcement authorities to consult with experts and to carry on deeper controls, before giving authorization for toys to be imported. In synthesis: the answer to the question Is it China's fault? is another question: Is it local enforcement agencies ' fault?  Anyway, the news related with toxics were so many this month, that we changed the title for the one above. Since our bulletins started, it's been not very often that we had to select between so many news. That's why this time we have such a huge bulletin. Let's hope it is of your interest.  Until the next number. JCP

Informan / Escriben
Experience on lactrodectus in Sonora ->

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Norberto Sotelo, Internal Medicine Head. Infantile Hospital of the State of Sonora, Mexico.
I had opportunity to see by Internet the presentation about  “Experience of SERTOX in spider envenenomation”  (Juan Carlos Piola) in Peru,  in July 2007. I observed with approval that included an appointment ours (Blak widow spider envenomation in children), Rev Mex Pediatr 2005; 72 (1): 31-35) I am thankful for this. In this occasion, I allow myself to send you the experience  in our Infantile Hospital of the State of Sonora, with the desire that it will be useful to you: “Lactrodectus Mactans spider envenomation in children - Blak widow.Clinical characteristic and treatment. Gac Méd Méx Vol.142, Nº 2, 2006”.
Note: we are thankful. indeed. Please, see the articles,  only available in Spanish

From ''La Quebrada'' ->

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Sandra Giunta. Educational investigator of the Faculty of Engineering of Jujuy, Ar.
I like me your magazine. I am directing 2 projects on essays  as  tools in eco toxicology of water and ground. We are working with heavy metal analysis in water and ground of the Quebrada of Humahuaca. I would like to be in contact with you to publish our results.

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Noticias del Sertox
2 x Radio 2: Office Printers contamination + products for lice ->

Apariciones en Medios Radiofónicos

  1. 08/06/07 interview to  Juan Carlos Piola,by Luis Novaresio (Programm “10 puntos”) about Office Printers contamination. Read more in: Office Printers Emit Ultrafine Particulates
  2. 08/17/07 interview to  Juan Carlos Piola,by Luis Novaresio (Programm “10 puntos”) about  Inadecuate products for lice head treatment. Only in Spanish: See related new . 

New videos about inhalants in Rosario ->

Apariciones en Televisión Only available in Spanish
1) Interview to Juan Carlos Piola ; Programm: De 12 a 14. Canal 3. Rosario. July 23,  2007.Time: 04' 20'' [Ver ]
2) Interview to Juan Carlos Piola ; Programm: Telenoche. Canal 3. Rosario. July 23,  2007. Time; 01' 49''. [ Ver ]
3) Interview to Daniel Ezpeleta; Programm: Plan A. Canal 3. Rosario.July 25,  2007 . Time: 04'52 ''.  [ Ver ]

Paper available on line ->

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Intoxication with Paracetamol liquid commercial presentation in children
Prada, Dora B.; Piola, Juan C.; Ezpeleta, Daniel C.; Evangelista, Marcela.
(Only available in Spanish)

References to papers by people of Sertox ->

Toxicología al día

References to  Eddleston M., Karalliedde L., Buckley N., Fernando, R., Hutchinson G., Isbister G.,Konradsen F., Murray D., Piola J. C., Senanayake R., Sheriff R., Singh S., Siwach S. B (2002) Pesticide poisoning in the developing world-a minimum pesticides list. Lancet 360, 1163-1167. See alsoabstract in Spanish. In:

  1. Review of the Forest Stewardship Council’s Pesticide.Indicators and Thresholds Report by Pesticide Action Network UK. Final Report.30th April 2005. Page 79.
  2. See others  62 citations in Google Scholar.
En Rede Latino-Americana – Européia sobre Governo dos Riscos:Governo dos Riscos; página 210 y 243 cita a "Piola JC, Ezpeleta DC. Revista de la Sociedad de Medicina Legal de Rosario, Ano 7 - Número 7. pág. 2-4. Dezembro de 1998".See (only available in Spanish): Valoración de marcadores de exposición al plomo en diagnóstico y vigilancia

Mecanismos de Acción Tóxica, by  Carmine Pascuzzo Lima cited  Piola JC. 1993. Tratamiento general del paciente intoxicado agudo.  Only available in Spanish.

News in Multimedia ->

Toxicología al día Now you can see in  Multimedia. Galería de videos externos, in Spanish and Selected videos (in English). You can see Safer chemicals within REACH | PCVN's Spider and Scorpion Guide | Alcohol intoxication | The Fine Art of Poisoning | Toxic Lead Smelting Operation in La Oroya, Peru | The Next Fifty Years of Science | Chemical Safety rap

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Toxicología al día
Drug addictions attention in Lanzarote ->

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We congratulated to the network of centers of attention to the drug addictions of Lanzarote, which has been awarded with the prestigious “Prize” Queen Sofía to the Social Work  that grants the Foundation of attention to the drug addictions of the Red Cross Spain (CREFAT), constituting one of the most important distinctions at national level in the action as opposed to the problematic one derived from the drug consumption. [ See more in Spanish ]

Congratulations for An Interesting Review ->

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Insulin & C-Peptide Levels in Sulfonylurea-Induced Hypoglycemia: A Systematic Review
Christopher R. DeWitt, Kennon Heard, Javier C. Waksman.
JOURNAL OF MEDICAL TOXICOLOGY, VOLUME 3, NUMBER 1, pages 107-118, SEPTEMBER 2007.
We have in PDF format (191 KB). If you wish, ask us and we'll send you.

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Aportes
Statin in the bench ->

Diarios, Revistas, Videos From Martín Cañas (To REDARTOX List)
An unusual judgment to a foreign laboratory
In 1998, to Flavio Rein the doctor prescribed Lipobay to him, a medicine to lower the cholesterol with statin. In the United States, the prospect indicated serious adverse effects, that in the local scope they were not mentioned. A month later, Rein was with serious adverse effects. [See in Spanish]
 
See also a related new, in Spanish: “The business is the cosmetic variation

Therapeutic Guide, Third edition ->

Artículos y Textos Científicos From Jordi Vilaseca and Jordi Espinas (To e farmacos List)
Only available in Spanish. See

Article about acute liver injury and the use of drugs ->

Artículos y Textos Científicos From  Martín Cañás (To e farmaco List)
"Risk of acute liver injury associated with the use of drugs: a multicentre population survey". M. SABATÉ, L. IBÁÑEZ, E. PÉREZ, X. VIDAL, M. BUTI, X. XIOL, A. MAS, C. GUARNER, M. FORNÉ, R. SOLÀ, J. CASTELLOTE, J. RIGAU, J.-R. LAPORTE (2007)
Alimentary Pharmacology & Therapeutics 25 (12), 1401–1409. [ Abstract ]

Papers of NEJM (August 2007) ->

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From Sergio L. García
Drug-Induced Immune Thrombocytopenia
Richard H. Aster,  and Daniel W. Bougie. www.nejm.org
N ENGL J MED 357;590-587 August 9, 2007. [ Full pdf ]

A Decade of Direct-to-Consumer Advertising of Prescription Drugs
Julie M. Donohue, Marisa Cevasco, and Meredith B. Rosenthal. www.nejm.org
N ENGL J MED 357:673-681  August 16, 2007  Number 7 [ Abstract ] [ Full pdf ]

Keeping the Artist Safe ->

Toxicología al día

From Guillermo Repetto (To TOXICOL List)
A new web page that addresses the hazards of arts and crafts
materials has been added to the National Library of Medicine (NLM)
Enviro-Health Links.
"Keeping the Artist Safe: Hazards of Arts and Crafts Materials"
Artists, craftspeople, and hobbyists use potentially hazardous
substances. Learn more about the hazards and how to protect yourself
from unnecessary exposures.

Restricted use for piroxicam, AE botulism toxin, and more ->

Toxicología al día

From Mariano Madurga  (To e farmaco List)

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La prensa
Diarios, Revistas, Videos
Diarios, Revistas, Videos · Pet Food Fall-Out Continues... ... * with Recalls, FDA Raids, Lawsuits Government Compensates Hog Fa... ARTÍCULO COMPLETO...
· DDT again? * DDT spray scares mosquitoes away, study finds. Reuters, Aug.8, 2007. Mosquitoes that c... ARTÍCULO COMPLETO...
· Import Seafood in USA * FDA Investigates Import Seafood Claims ( Washingtonpost, 08/09/07) The Food ... ARTÍCULO COMPLETO...
· About unapproved medicines * Court sees no right to unapproved medicines . Reuters, Aug 7, 2007. Ter... ARTÍCULO COMPLETO...
· Chinese-made toys with lead * 08/02/07. Mattel's Fisher-Price recalling 1.5 mln toys Mattel Inc. is... ARTÍCULO COMPLETO...
· Girl overdoses on espresso coffee BBC news. 13 August 2007- A teenager was taken to hospital after ov... ARTÍCULO COMPLETO...
· Kids and lead poisoning * Lead poisoning fears send families to clinics (Indistar.com, August 15, 2... ARTÍCULO COMPLETO...
· About Codeine Risk * FDA Warns Nursing Mothers of Possible Codeine Risk. Washingtonpost.com. Aug. 1... ARTÍCULO COMPLETO...
· Monoxide poisoning (USA) * 23 Near Va. Tech Hospitalized With Monoxide Symptoms. Washingtonpost.com... ARTÍCULO COMPLETO...
· And now: toxic clothes * Toxic clothes - The tip of the iceberg? Scoop.co.nz. August 20, 2007. Dang... ARTÍCULO COMPLETO...
· Bad behaviour * Police crack down on scavengers. BBC news. Aug 23,2007 The "despicable" behaviour ... ARTÍCULO COMPLETO...
· Toxic in Germany's children * Pollutants More Likely To Hit Underprivileged Children. DW-World.de.A... ARTÍCULO COMPLETO...

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zNo sólo de tóxicos
We also need: BODIES...The Exhibition ->

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BODIES...The Exhibition Celebrate the wonder of the human form in the World Premier of BODIES...The Exhibition . See

For the Kids...(and their parents too). ->

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From the National Capital Poison Center, Washington, USA
For Kids, by kids:
Poisons are dangerous! It's important to try to be as safe as possible when around them. Most poison prevention programs are too hard to understand from a kid's point of view. The dangers and what to do are not clear. Here is a website specially formulated for kids. Have fun learning.
Poison Prevention Jingles: Listen to music and sing alone!
See Preschool video of Spike Poisoning Prevention also in http://www.poison.org/prevent/preVideo.asp

Image July/2007 BMC Cell Biology ->

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Localization of activated Smads on early endosomes in chicken embryo lenses.
The early endosomal marker EEA1 is stained in green and pSmad1/5/8 in red. Nuclei stained with the dye TOPRO are blue. Vesicles in which pSmad1/5/8 and EEA1 co-localize appear yellow and nuclei stained with pSmad1/5/8 and TOPRO are magenta. See in original site

I see the stars ->

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Google Earth given celestial view. BBc news.Aug 22,2007.  The constellations of Andromeda, Hydra and Vulpecula are now just a mouse click away for amateur star-gazers, following the launch of Google Sky. [See ] and Watch video.

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Recomendamos
Carbon monoxide video ->

Diarios, Revistas, Videos Taking care of Simón
Authors: Jorge Roman Iriarte, Alexander Gallo, Jeronimo Adrien and Matías Plonsky.
First prize in National Aid by the prevention against the contamination by carbon monoxide, Spain, 2006. Duration: 1 minute, 32 seconds. [ see in Spanish ]

Office Printers Emit Ultrafine Particulates ->

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Toner particles from laser printers found in air
Office workers now have reason to think twice before printing out that report the boss is waiting for. In a recent office study, researchers in Australia found that nearly one-third of laser printers emitted high levels of nanoparticles into the air, and on average, particle counts during working hours were five times higher than during nonwork hours (Environ. Sci. Technol., DOI: 10.1021/es063049z.). Inhaling these ultrafine particles may pose a health hazard, experts caution. [ See ]

Recurrent ventricular fibrillation in magnesium fluosilicate poisoning ->

Artículos y Textos Científicos Only available in Spanish [ See ]

Articles from American Family Physician, Latest issues ->

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July 1, 2007 Vol. 76 No. 1
Evaluation of Nausea and Vomiting
KEITH SCORZA, MD, AARON WILLIAMS, DO, J. DANIEL PHILLIPS, MD, and JOEL SHAW, MD.Dewitt Army Community Hospital Family Medicine Residency, Fort Belvoir, Virginia
 A comprehensive history and physical examination can often reveal the cause of nausea and vomiting, making further evaluation unnecessary. Acute symptoms generally are the result of infectious, inflammatory, or iatrogenic causes. [ See ] [pdf ]

August 1, 2007 Vol. 76 No. 3
The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects
TOM LYNCH, PharmD, and AMY PRICE, MD, Eastern Virginia Medical School, Norfolk, Virginia
Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a patient's response to commonly prescribed drug classes, including beta blockers and antidepressants. [ See ][pdf ]

Last number ->

Artículos y Textos Científicos WHO Drug Information Volume 21, Number 2, 2007

Made diseases ->

Artículos y Textos Científicos It is the name of the editorial of the Bulletin Nº 17, Farmacovigilancia, July-august 2007, INVIMA, Colombia. Only available in Spanish. [ See ]

Pharmacolgy book on line (In Spanish) ->

Artículos y Textos Científicos Only available in Spanish. Farmacología Básica, 2007. Author: Carmine Pascuzzo-Lima, Professor Asociated, Universidad Centroccidental “Lisandro Alvarado” (UCLA), Venezuela.

Antidepressant in pregnant women ->

Artículos y Textos Científicos Prevalence and predictors of antidepressant use in a cohort of pregnant women
É Ramos, D Oraichi, É Rey, L Blais, A Bérard
BJOG: An International Journal of Obstetrics and Gynaecology (OnlineEarly Articles).
doi:10.1111/j.1471-0528.2007.01387.x [ Full text ]

About Malignant Hyperthermia ->

Toxicología al día "The sudden unexpected death of a healthy individual undergoing minor surgery is a tragedy almost beyond comprehension in this day of modern medical miracles"
From a newspaper news, in Spanish (See Diario La Capital (08/07/07,Investigan muerte de un joven durante operación de vesícula) it is usefull remember the Web of  MHAUS. You can see also Dantrolene Mixing Video. And a link to Neuroleptic Malignant Syndrome Information Service -( NMSIS).

Recommended link: september/07 ->

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The Health-EU Portal is directed at those who want to keep informed about issues affecting their health, and at those who wish to keep up to date with policies and decisions taken at European, national and international level. The Portal is also an important source of information for health professionals, administrations, policy makers and stakeholders.You can read: Chemical risks, Environmental Health, and more. Available in English and in 21 languages more.

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