Bienvenido al ::: SerTox :::!

     Menú
· Noticias
· Institucional
· Investigación
· Materiales Educativos
· Biblioteca multimedia
· Preguntas frecuentes
· Boletín
· Buscar
· Contáctenos
· Enlaces - Directorio
· Glosario
· Noticias x Mes
· Temas
· Top 15

EnglishSpanish

     Buscar


     Categorías
· Todas las Categorías
· Aportes
· Ejercicios
· Informan / Escriben
· La prensa
· Noticias del Sertox
· Recomendamos
· Toxicología al día
· Trivia toxicológica
· zNo sólo de tóxicos

     Blogs



     Manifiesto amianto





 Toxicología al día: Chronic Marijuana Use May Affect Pituitary Hormones

Ver Imagen

Hoja de marihuana (Foto: Sertox )

Case Study Links 'Pot' to Pituitary Damage. By Cole Petrochko. MedPageToday.May 03, 2013. Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania.  Chronic, daily pot smoking over 15 years may be draining on pituitary hormones, and may explain the "pot-head" image popularized in movies and TV, according to a case report presented here. A hormonal evaluation of a patient with symptoms of loss of libido, fatigue, and dyspnea showed luteinizing hormone concentration of 0.2 mIU/mL, follicle-stimulating hormone concentrations of 1.8 mIU/mL, and testosterone concentrations of 22 ng/dL, according to Richard Pinsker of Jamaica Hospital Medical Center in Queens, N.Y., and colleagues.


The patient also showed deficiencies in thyroxine and cortisol production, Pinsker said during an oral presentation at the meeting of the American Association of Clinical Endocrinologists.

Tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, can impair gonadotropin-releasing hormone, as well as affecting other neural transmitters in the hypothalamus, which can result in clinical hypopituitarism, the researchers noted.

"This is a single case, but an interesting case and a hypothesis-generating case," noted R. Mack Harrell, MD, FACP, vice president of the AACE and who was not involved in the study.

He added that this case "takes it to a whole other level -- all of the pituitary hormones were out in this patient."

The study followed a 37 year-old patient who reported daily marijuana use for 15 years and presented to the Jamaica Hospital Medical Center emergency department with symptoms of increasing fatigue, loss of libido, and dyspnea on exertion.

The patient had no history of radiation exposure or head trauma and normal iron and echocardiography, but had significant symptoms of bibasilar rales, gynecomastia, and bilateral atrophied testis on physical examination.

In addition, tests for commonly prescribed opioids turned up negative.

The patient's hormones were measured and, in addition to lower levels of testosterone, follicle-stimulating hormone, and luteinizing hormone, the patient presented with elevated levels of prolactin (53.3 ng/mL), low total T3 (30 ng/dL), high T3 resin reuptake (49%), low total T4 (3.94 ug/dL), normal free T4 (0.97 ng/dL), and low thyroid-stimulating hormone (0.22 uLU/mL).

A subsequent MRI of the patient's head showed an enlarged protuberant pituitary gland without an identified mass lesion.

The patient received a morning dose of 25 mg cortisone, 12.6 mg bedtime cortisone, and daily 25 mcg levothyroxine treatment, which improved his fatigue and edema "dramatically."

Pinsker noted that this issue may be under-addressed, in part because cannabis is not frequently tested for as part of screening for hypopituitarism and due to an increasing political climate supporting marijuana legalization.

"The whole trick was to identify [the patient's marijuana use], and I think we're missing a tremendous amount of people in the United States who have had damage to their pituitary from the use of marijuana," Pinsker told MedPage Today, cautioning that "patients have to be aware and give doctors the scoop on what's going on in their outside lives."

He added that follow-up studies should look at more subjects or individual cases to see if the problem is more wide spread.

Primary source: American Association of Clinical Endocrinologists
Source reference:
Pinsker R, et al "Chronic marijuana use as a potential cause of hypopituitarism" AACE 2013; Abstract 825.

Enviado por jcp el 06 mayo 2013 00:00:00 (645 Lecturas)






Artículos e imágenes de:
 Artículos y Textos Científicos
Artículos y Textos Científicos
Aportes de Javier Waksman
Aportes de Javier Waksman
 Drogas: Marihuana / Cannabis
Drogas: Marihuana / Cannabis
 País: Estados Unidos y Canadá
País: Estados Unidos y Canadá

 
     Enlaces Relacionados


Noticia más leída sobre Artículos y Textos Científicos:
De Martín Cañás: Herbalife + hepatotoxicidad


     Votos del Artículo
Puntuación Promedio: 0
votos: 0

Por favor tómate un segundo y vota por este artículo:

Excelente
Muy Bueno
Bueno
Regular
Malo


     Publicidad






Todos los logos y marcas registradas son propiedad de sus respectivos dueños. Los comentarios son propiedad de quienes lo envían, todo el resto © 2006-2011 by Sertox.

Webs Asociadas: www.country2.com / Radio FM Estacion San Pedro / Lombó Teatro Salamanca - Zamora

PHP-Nuke Copyright © 2005 by Francisco Burzi. This is free software, and you may redistribute it under the GPL. PHP-Nuke comes with absolutely no warranty, for details, see the license.
Página Generada en: 0.04 Segundos