Bienvenido al ::: SerTox :::!

· Noticias
· Institucional
· Investigación
· Materiales Educativos
· Biblioteca multimedia
· Preguntas frecuentes
· Boletín
· Buscar
· Contáctenos
· Enlaces - Directorio
· Glosario
· Noticias x Mes
· Temas
· Top 15



· Todas las Categorías
· Aportes
· Ejercicios
· Informan / Escriben
· La prensa
· Noticias del Sertox
· Recomendamos
· Toxicología al día
· Trivia toxicológica
· zNo sólo de tóxicos


     Manifiesto amianto

 Toxicología al día: Pregnant women who take acetaminophen might raise the risk that their child will develop ADHD

Ver Imagen

Supositorios de paracetamol (Foto: WP)

Acetaminophen During Pregnancy May Up Risk of ADHD in Kids. August 15, 2016.But only association found, and researchers say women should still take the painkiller if needed. Pregnant women who take acetaminophen -- best known as Tylenol -- might raise the risk that their child will develop behavioral problems such as attention-deficit/hyperactivity disorder (ADHD), a new study suggests. Acetaminophen is generally considered safe in pregnancy -- so safe, in fact, that at least two-thirds of women turn to it while expecting, according to the American Academy of Family Physicians.

But when pregnant women in Britain used the pain reliever, it appeared to increase the risk of behavior problems cropping up in their children by the time they turned 7, said lead researcher Evie Stergiakouli, a lecturer in genetic epidemiology at the University of Bristol.

Still, the study couldn't prove cause-and-effect, and Stergiakouli believes that women should still take the drug if needed.

In the study, taking acetaminophen between 18 and 32 weeks in pregnancy was associated with a 42 percent increased risk of behavior problems in children and a 31 percent increased risk of hyperactivity, the researchers found.

The investigators also saw a 29 percent increased risk of emotional problems and a 46 percent increased risk of overall behavioral difficulties in children of women who used acetaminophen at 32 weeks of pregnancy.

No similar association cropped up in mothers who used acetaminophen after delivery, nor did it occur if the father used the over-the-counter drug, the findings showed.

"Only acetaminophen use during pregnancy has the potential to cause behavioral problems in the offspring," Stergiakouli said.

These findings jibe with two other large-scale studies that have suggested acetaminophen may have an adverse effect on a baby's brain during pregnancy, said Dr. Andrew Adesman. He is chief of developmental and behavioral pediatrics at Cohen Children's Medical Center in New Hyde Park, N.Y.

However, Adesman noted that a mom who needs the pain reliever will not automatically condemn her child to future behavioral problems.

"Although sophisticated statistical testing did indeed demonstrate an increased risk for behavior and emotional problems following prenatal exposure to acetaminophen, it is important to remember that the overwhelming majority of children exposed prenatally to acetaminophen do not end up having any of these behavioral or emotional problems," Adesman said.

Stergiakouli believes pregnant women may still have good reason to take acetaminophen.

"There is a risk of not treating fever or pain during pregnancy, and this should be carefully weighed against any potential harm to the offspring," she said. "For example, untreated fever during pregnancy can lead to premature labor."

Dr. Noel Strong, an assistant professor of obstetrics, gynecology and reproductive science with the Icahn School of Medicine at Mount Sinai in New York City, said the new study is "not going to make me change my current practice."

"It's demonstrating an association, but it's a mild association at best," Strong said. "It still appears to me to be our safest pain medication for use in pregnancy. The study won't make me abandon that -- yet."

For the long-term study, Stergiakouli and her colleagues analyzed data for almost 8,000 mothers who enrolled in the study between 1991 and 1992, along with their children and partners.

Questionnaires assessed the women's acetaminophen use at 18 and 32 weeks during pregnancy, and again when their children were 5 years of age. A follow-up questionnaire assessed behavioral problems in children as reported by mothers when the kids turned 7.

About 53 percent of the mothers reported using acetaminophen at 18 weeks of pregnancy, and 42 percent said they used the pain reliever at 32 weeks, the findings showed.

About 5 percent of the children developed behavioral problems. This was similar to National Health Service estimates that 2 percent to 5 percent of school-aged British children have ADHD, but far below the 11 percent reported in the United States.

The findings were published online Aug. 15 in the journal JAMA Pediatrics.

The researchers speculated that acetaminophen might affect fetal brain development by altering a mother's hormone levels, or by crossing the placenta and directly affecting the unborn child.

ADHD is a complex disorder involving many different potential factors, Strong said, and it's unlikely that any single element causes it.

"There are many degrees of separation and many bridges of evidence that would have to be crossed before you can establish a causal relationship," Strong said. "This needs a lot more science behind it."

These studies only show a potential association and do not prove a cause-and-effect link between acetaminophen and behavior problems, Tylenol manufacturer McNeil Consumer Healthcare said in a statement.

"It is important to note there are no studies demonstrating a causal link between acetaminophen use during pregnancy and adverse effects on child development," the company said. "The authors of the recent study in JAMA Pediatrics stated that further studies are required to determine a causal explanation, and that the benefits of using any medication during pregnancy should be carefully weighed against any risks."

SOURCES: Evie Stergiakouli, Ph.D., lecturer, genetic epidemiology, University of Bristol, United Kingdom; Andrew Adesman, M.D., chief, developmental and behavioral pediatrics, Cohen Children's Medical Center, New Hyde Park, N.Y.; Noel Strong, M.D., assistant professor, obstetrics, gynecology and reproductive science, Icahn School of Medicine at Mount Sinai, New York City; McNeil Consumer Healthcare statement


Enviado por jcp el 17 agosto 2016 00:00:00 (156 Lecturas)

Artículos e imágenes de:
 País: Estados Unidos y Canadá
País: Estados Unidos y Canadá

     Enlaces Relacionados

Noticia más leída sobre Medicamentos:
Advierten que interacción de fenilefrina y acetaminofén podría provocar efectos secundarios graves

     Votos del Artículo
Puntuación Promedio: 0
votos: 0

Por favor tómate un segundo y vota por este artículo:

Muy Bueno


Todos los logos y marcas registradas son propiedad de sus respectivos dueños. Los comentarios son propiedad de quienes lo envían, todo el resto © 2006-2011 by Sertox.

Webs Asociadas: / Radio FM Estacion San Pedro / Lombó Teatro Salamanca - Zamora

PHP-Nuke Copyright © 2005 by Francisco Burzi. This is free software, and you may redistribute it under the GPL. PHP-Nuke comes with absolutely no warranty, for details, see the license.
Página Generada en: 0.04 Segundos