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adults, the estimated lethal dose varies from 50 to 300 mg of inorganic
compounds (Armstrong et al., 1984; Hindmarsh, 1986;Vallee, 1960; Zaloga et al.,
For As2O3, the lowest reported lethal dose is about 120 mg (Arena,
The fatal dose of ingested arsenic trioxide has also been reported to
lie between 70 and 180 mg (Vallee, 1960).
Severe toxicity has been reported
with the ingestion of as little as 1 Mg As203, but as little as 20 mg can be
life threatening (Schoolmeester et al., 1980; Winship, 1984).
exposure to dusts or aerosols containing arsenic occurs mainly in industry
(smelting of ores) or
agriculture (mixing and/or spraying pesticides) and can
produce toxic effects on the respiratory tract along with systemic effects.
ACGIH (1995) consider arsenic, elemental (7440-38-2) and inorganic arsenic
(except arsine) as a confirmed human carcinogen, and has set up the
standard for arsenic at 0,01
mg/m3 (TLV-TWA: Threshold Limit Value - Time -
- ACGIH (1995) has adopted also a Biological Exposure
Indice (BEI) for arsenic and soluble
compounds including arsine (7784-42-1)
of 50 µg/g creatinine (inorganic arsenic metabolites in
uriine), for a
sampling time at the end of the workweek.